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Substrate binding in TsrM. (A) Shared reaction of rSAM enzymes. (B) Reaction catalyzed by TsrM, which while annotated as a rSAM enzyme, does not appear to generate dAdo•. (C) The active site structure of TsrM (PDB accession code: 6WTF) depicts the target carbon in an unproductive position. Docking simulations suggest an alternate flipped binding mode for Trp in the presence of MeCbl. This proposal helps to rationalize observed reorientation of a nearby Tyr.
