Figure 1.

The mechanism of transcriptional modulation mechanism by ROR and REV-ERB. ROR and REV-ERB are ligand-dependent transcription factors. Ligand binding triggers conformational alterations in both ROR or REV-ERB. As a result, they recruit co-activators or co-repressors to ultimately boosts or represses target gene transcription. REV-ERB and ROR are often co-expressed, and both specifically recognise RORE. Consequently, ROR and REV-ERB competitively bind to RORE present in the regulatory region of target genes, forming a mutually antagonistic relationship. In most cases, ROR recruits co-activators and promotes gene transcription, whereas REV-ERB recruits co-repressors and inhibits gene transcription.