Table 1.
Comparison of the amino acid residues arising due to hydrogen bond and Van de waals interaction at the binding site of PPARγ with the presence of rosiglitazone and THCB.
| Type of Interaction | Ligand | Amino Acid Residue that Contribute to Binding of Ligand Towards PPARγ |
|---|---|---|
| Hydrogen Bond | Rosiglitazone | SER342, SER289, CYS 285 |
| THCB | ARG280, GLN283 | |
| Van der waals | Rosiglitazone | GLY284, TRY327, PHE363, GLN286, LEU453, LEU469, LEU465, TYR473, HIS323, ILE326, VAL339, ILE341 |
| THCB | GLU259, ILE281, LEU255, GLN273, GLY284, LYS275, HIS 466 |