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. 2021 Apr 29;26(9):2593. doi: 10.3390/molecules26092593

Figure 2.

Figure 2

Binding sites of naproxen to N NTD monomer and dimer; comparison with naproxen derivatives. Naproxen is shown in (A), with details on its functional moieties as discussed in the text. Panels (B,C) show the binding sites of naproxen on monomeric N NTD (PDB 7ACT) [28], the main (more frequent) binding site represented in cyan, is associated with the dimeric interface, highlighted in (C) in yellow; the minor site of naproxen on monomeric N NTD is represented in green. In panels (D,E) is shown the main binding site of naproxen on dimeric N NTD (PDB 6VYO) [27]. For details, see also Supplementary Figure S2. The structures of naproxen A and C0 are shown in panels (F) and (G), respectively. Panel (H) summarizes the RNA binding site (shown in green) deduced from RMN studies [28], the main binding site of naproxen on the left and the main binding site of naproxen C0, located within the RNA binding groove. (See also Table 1 and Supplementary Figure S2).