Levels of soluble proteins by hepatitis C virus (HCV) serostatus among patient groups. IL1β: relative to controls, lower in AUD (p = 0.008), HIV (p = 0.001), HIV+HCV (p = 0.007), AUD+HIV (p = 0.001), AUD+HIV+HCV (p = 0.002). IP10: relative to controls, higher in AUD+HCV (p < 0.0001), HIV (p = 0.02), HIV+HCV (p < 0.0001), AUD+HIV (p = 0.5), AUD+HIV+HCV (p < 0.0001). Higher in AUD+HCV vs. AUD (p < 0.0001), HIV+HCV vs. HIV (p = 0.009), AUD+HIV+HCV vs. AUD+HIV (p = 0.0008). black circles: healthy controls; open squares: AUD; filled squares: AUD+HCV; open triangles: HIV; filled triangles: HIV+HCV; open diamonds: AUD+HIV; filled diamonds: AUD+HIV+HCV.