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. 2021 May 7;22(9):4953. doi: 10.3390/ijms22094953

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Path analysis describing relationships between relevant variables, soluble protein levels, and subcortical white matter volume (WM). Path analysis includes 3 factors (reduced from 15 variables entered into principal component analysis (PCA)), 3 soluble proteins, and subcortical white matter in the HCV and HIV groups (n = 127). Factor 1 (6 variables) includes HCV viral load, fibrosis score (FIB4), aspartate aminotransferase/platelet count ratio (APRI), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (GGT). Factor 2 (5 variables) includes injection drug use (IDU), VACS index, creatinine, estimated glomerular filtration rate (eGFR), and prealbumin. Factor 3 (3 variables) includes HIV viral load, total HIV conditions, and the albumin-to-globulin ratio (AGR).