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. 2021 May 3;22(9):4837. doi: 10.3390/ijms22094837

Table 4.

Differential diagnosis of serotonin syndrome.

Toxidromes
(Main Etiological Factors)		 Common Symptoms Different Symptoms
Anticholinergic syndrome
(Dopamine antagonists)		 Altered mental status, hot dry skin Normal reflexes, no clonuses
Neuroleptic malignant syndrome
(low dopamine)		 Bradykinesia, rigidity, hyperthermia,
fluctuating mental status		 Symptoms usually develop over
several days
Malignant hyperthermia
(Inhalation anesthesia,
Succinylcholine)		 Hyperthermia, hypertonicity
Sympathomimetic syndrome Tachycardia, hypertension,
altered mental status		 No neuromuscular abnormalities,
no clonuses