Table 2.
The therapeutic effect of 212Pb-NG001 in athymic nude mice with C4-2 xenografts. The therapeutic index (TI) was calculated from median survival and median time for tumours to reach a volume of 1.5 cm3 in the treatment groups compared to the control group.
| Treatment Group | Number of Mice | Median Survival (Days) | Median Time for Tumour to Reach 1.5 cm3 (Days) | TI, Median Survival (p Value) | TI, Tumour Volume (p Value) |
|---|---|---|---|---|---|
| Study 1 | |||||
| Control | 7 | 23 | 17.0 | ||
| 0.25 MBq 212Pb-NG001 | 8 | 35 | 30.5 | 1.5 (<0.001) | 1.8 (0.002) |
| Study 2 | |||||
| Control | 8 | 16.5 | 15.0 | ||
| 0.30 MBq 212Pb-NG001 | 8 | 38.5 | 37.5 | 2.3 (0.012) | 2.5 (0.015) |
| Study 3 | |||||
| Control | 6 | 27 | 25.5 | ||
| 0.40 MBq 212Pb-NG001 | 6 | 74 | 64.0 | 2.7 (<0.001) | 2.5 (0.002) |