Table 4.

Therapeutic effect of various radiolabelled PSMA ligands in different subcutaneous animal models. Table S1 provides details of the mouse strains and cell lines used and specific activities in each individual study. The therapeutic index (TI) is calculated as the median survival of the treatment group divided by that of the control group.

Radioligand	Injected Activity Range	Therapeutic Index Range	References
212Pb-NG001	0.25–0.40 MBq	1.5–2.7	Current study
212Pb-L2	1.5–3.7 MBq	1.9–3.0	[24]
177Lu-PSMA-617	2–111 MBq	1.7–4.1	[3,30,36,58,59,60]
225Ac-PSMA-617	0.02–0.1 MBq	1.1–6.7	[59,61]