Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
MCs play proinflammatory and anti-inflammatory roles. MCs are activated by various stimuli such as IgE crosslink, ATP, cations, IL-33, and LPS, via FcεRI, P2X7, MRGPRX2 (Mrgprb2), IL-33R, and TLR4, respectively. MC activation is followed by degranulation and the release of cytokines and eicosanoids. MCs also exhibit anti-inflammatory function including the production of IL-10 in certain circumstances [70,76]. SP: Substance P.
