Table 1.
Effects of IL-10 on proliferation and survival of MCs.
| Effects | in | Strain | MC Type | Condition | Response | Ref. |
|---|---|---|---|---|---|---|
| Promotive | vitro | C57BL/6 | Nb-infected MLN SCF+IL-10 | 7 days | Proliferation ↑ | [38,39,40,41,42] |
| BMMC IL-3+SCF | IL-10, 24 h | |||||
| Upper airway tract IL-3+SCF | IL-10, 24 h | |||||
| C3H/HeN | Splenocytes IL-3 | IL-10, 2–4 days | ||||
| BALB/c | BMMC IL-3+SCF+IL-10 | 8 days | ||||
| 21 days | ||||||
| IL-10-/- (Balb) | BMMC IL-3+SCF | 8 days | Proliferation ↓ | |||
| vivo | IL-10-/- (B6) | MMCs (T. spiralis-infected MLN) | 8 days | MC number ↓ | [42,43] | |
| NIH | Anti-IL-10 Ab i.p. 11–15 days | |||||
| IL-10-/- (Balb) | Jejunal MC | OVA-induced FA | ||||
| Suppressive | vitro | C57BL/6 | BMMC W+IL-10 | 14–21 days | Apoptosis ↑ | [41,44,45,46,47] |
| BMMC W | IL-10, 14 days | |||||
| IL-10, 6 days + IgE-XL | ||||||
| Human | Fetal liver monocytes SCF | IL-10, 7 days | ||||
| C57BL/6 | BMMC W | IL-10, 2–7 days | ||||
| BALB/c | IL-10, 3 days | |||||
| IL-10-/- (B6) | BMMC IL-3+SCF | 21 days | Proliferation ↑ |
Subscripts in the line of MC type indicate the supplements in the culture media. Abbreviations: Balb; BALB/c, B6; C57BL/6, Nb; Nippostrongylus brasiliensis, MLN; Mesenteric Lymph Node, W; WHEI-3 conditioned medium, Ab; Antibody, i.p.; intraperitoneally injection, FA; Food Allergy, IgE-XL; IgE crosslink. Symbols: ↑; up-regulated, ↓; down-regulated.