. 2021 May 7;22(9):4972. doi: 10.3390/ijms22094972

Table 2.

Effects of IL-10 on function of MCs.

Effects	Strain	MC Type	Condition		Stimuli	Response	Ref.
Suppression	C57BL/6	BMMC _IL-3 or BMMC _W	IL-10	4 days	-	FcεRI ↓	[26,55]
	BALB/c	BMMC _IL-3
	C3H
	129
	C57BL/6	BMMC _IL-3		5–14 days	- or IgE
	Human	Skin MC or Lung MC		4 days	-
	C57BL/6	BMMC _{IL-3 or W}		4 days	IgE-XL	TNF-α ↓	[26,42,47,55,56,57]
		BMMC _IL-3+SCF		16 h	IgE-XL	TNF-α ↓
		BMMC _W		24 h	SCF	TNF-α, IL-13 ↓
	Brown North rat	PMC		1–18 h	IgE-XL, LPS, PGE_{1, 2}	Histamine, IL-6 ↓
	Lewis rat	PMC		1–18 h	LPS	TNF-α, IL-6 ↓
	Sprague-Dawley rat	PMC (Nb-infected)		24 h	IgE-XL	TNF-α, Histamine, Nitrite ↓
	Human	Skin MC		4 days		Degranulation, GM-CSF ↓
	BALB/c	BMMC _IL-3+SCF		24 h		TNF-α, IL-4↓
	Sprague-Dawley rat	PMC (Nb-infected)	Anti-IL-10 Ab 24 h	6 h	- or IgE-XL	TNF-α ↑	[57]
	Human	CBMC		24 h	IgE-XL	LTC₄, D₄, E₄ IL-5, IL-8 ↑	[58]
	Human	CBMC		12 h, IgE-XL	IgE-XL	TNF-α ↑	[58]
	CD68-IL-10 Tg (B6)	-	PSA		-	TNF-α, MIP-1α ↓, Δ of body temperature ↓	[55]
Promotion	C57BL/6	BMMC _{IL-3 or W}	IL-10	4 d	IgE-XL	Degranulation ↑	[26,40,42,59]
	BALB/c	BMMC _IL-3+SCF		7 d		TNF-α, IL-6, IL-13 ↑
	C57BL/6	BMMC _IL-3+SCF		24 h		IL-6, IL-13, MCPT-1 ↑
	C57BL/6	PMC _IL-3+SCF				IL-6, IL-13 ↑
	C57BL/6	Upper airway tract _IL-3+SCF				Degranulation ↑
	Human	Skin MC				MCP-1 ↑
	C57BL/6	-	PSA (IL-10 i.p.)		-	Histamine, IL-6, MIP-1α ↑, Δ of body temperature ↑
	BALB/c	BMMC _IL-3+SCF	IL-10	24 h	LgE-XL	IL-6, IL-13 ↑	[42]
	IL-10^-/- (Balb)	-	OVA-induced FA		-	Diarrhea, MC number, Activation ↓	[42]

Subscripts in the line of MC type indicate the supplements in the culture media. Abbreviations: Tg; Transgenic, B6; C57BL/6, Balb; BALB/c, W; WHEI-3 conditioned medium, Nb; Nippostrongylus brasiliensis, Ab; Antibody, PSA; Passive Systemic Anaphylaxis, i.p.; intraperitoneally injection, FA; Food Allergy, IgE-XL; IgE crosslink. Symbols: ↑; up-regulated, ↓; down-regulated, Δ; decrease.