Table 1.
List of the 35 total molecule mediating METH, HMGB1, and APP.
| Symbol | Entrez Gene Name | Location |
|---|---|---|
| AGER | advanced glycosylation end-product specific receptor | Plasma Membrane |
| Akt | Akt | Cytoplasm |
| CAMK4 | calcium/calmodulin dependent protein kinase IV | Nucleus |
| CASP3 | caspase 3 | Cytoplasm |
| caspase | caspase | Cytoplasm |
| Ccl2 | chemokine (C-C motif) ligand 2 | Extracellular Space |
| CSF2 | colony stimulating factor 2 | Extracellular Space |
| Cytokine * | cytokine | Extracellular Space |
| EPO | Erythropoietin | Extracellular Space |
| ERK | Extracellular Receptor Kinase | Other |
| FAS | Fas cell surface death receptor | Plasma Membrane |
| HMOX1 | heme oxygenase 1 | Cytoplasm |
| HSF1 | heat shock transcription factor 1 | Nucleus |
| ICAM1 | intercellular adhesion molecule 1 | Plasma Membrane |
| IFNG | interferon gamma | Extracellular Space |
| IgG | immunoglobulin G | Extracellular Space |
| IL1 | interleukin 1 | Extracellular Space |
| IL6 | interleukin 6 | Extracellular Space |
| IL1A | interleukin 1 alpha | Extracellular Space |
| IL1B | interleukin 1 beta | Extracellular Space |
| IL1R1 | interleukin 1 receptor type 1 | Plasma Membrane |
| Jnk | c-Jun N-terminal kinase | Cytoplasm |
| Mapk | Mitogen-activated protein kinase | Cytoplasm |
| MAPK1 | mitogen-activated protein kinase 1 | Cytoplasm |
| MAPK3 | mitogen-activated protein kinase 3 | Cytoplasm |
| MAPK8 | mitogen-activated protein kinase 8 | Cytoplasm |
| MMP2 | matrix metallopeptidase 2 | Extracellular Space |
| MMP9 | matrix metallopeptidase 9 | Extracellular Space |
| PARP1 | poly(ADP-ribose) polymerase 1 | Nucleus |
| Pro-inflammatory Cytokine * | Pro-inflammatory cytokine | Other |
| RELA | RELA proto-oncogene, NF-kB subunit | Nucleus |
| TGFB1 | transforming growth factor beta 1 | Extracellular Space |
| TLR2 | toll like receptor 2 | Plasma Membrane |
| TLR4 | toll like receptor 4 | Plasma Membrane |
| TNF | tumor necrosis factor | Extracellular Space |
| TP53 | tumor protein p53 | Nucleus |
* Indicates complex groups/complexes—their members will have the same predicted activity. Members of Pro-inflammatory Cytokine: CD40LG, CD70, CLCF1, CNTF, CSF2, CXCL8, Eda, EDA, FASLG, IFNG, IL11, IL12A, IL12B, IL13, IL15, IL17A, IL17B, IL17C, Il17d, IL17D, IL17F, IL18, IL1A, IL1B, IL1F10, IL2, IL21, IL25, Il3, IL3, Il31, IL31, IL33, IL36A, IL36B, IL36G, IL37, IL4, IL5, IL6, LEP, LIF, LTA, LTB, OSM, TGFB1, TGFB2, TGFB3, TNF, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF4, TNFSF8, Tnfsf9, TNFSF9. Members of Cytokine:IL1A, IL1B, IL9.