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. 2021 May 6;13(9):2219. doi: 10.3390/cancers13092219

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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High abundance of VISTA+, CD11b+ cells combined with low abundance of CD8+ T-cells in tumor associates with low OS in MM. (A) Correlation plot between preferential CD8 T-cell density and preferential VISTA+, CD11b cell density (see Results for details). (B) Immunofluorescence image showing one patient with low OS (0.9 months, left-hand side) and another patient with high OS (89 months, right-hand side). Tumor area is encircled by cyan line. Relative abundance of VISTA+, CD11b+ cells (orange) in tumor area compared to CD8 T-cells (green) associates with low OS, whereas low abundance of VISTA+, CD11b cells in tumor area compared to CD8 T cells is associated with high OS. (C–E) Kaplan-Meier estimates showing OS for tumoral abundance of CD8 T-cells (C), VISTA+, CD11b+ cells (D), and the combination of these two parameters.