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. 2021 May 4;22(9):4864. doi: 10.3390/ijms22094864

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Most significant (p < 0.001) biological processes of protein subnetwork are shown as interconnected dots which color and width indicates the GO term significance and the number of proteins associated to each term, respectively (A). Differentially expressed protein found to be significantly up- or downregulated (p < 0.05, |FC| = 1.5) of the neutrophil degranulation (B) and IL-12-mediated signaling pathways (C) are shown. (D) Representative images of western blot analyses for AnnexinA2, S100A8 and S100A9.