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Representation of the different bindings between VEGF/VEGFR and the molecules inhibiting their signaling pathways. The mammalian VEGF family is composed of five members: PIGF, VEGF-A, VEGF-B, VEGF-C and VEGF-D. These different members bind VEGFR: VEGFR-1, VEGFR-2, and VEGFR-3. These receptors are present on the surface of various cells indicated under the receptor. Various inhibitors can target the VEGF/VEGFR signaling pathways.
