Disease-alleviating effect of oxyresveratrol (OXY) in a dextran sulfate sodium (DSS)-induced colitis rat model (n = 8/group). Daily changes of body weight (A), stool consistency (B), and rectal bleeding (C) were monitored, and the disease activity index (DAI) score was calculated by summing scores of these three parameters (D). NC, normal control group; model, DSS-induced colitis model group; DSS + OXY-2.5, DSS-induced colitis rats treated with OXY (2.5 mg/kg) group; DSS + OXY-5, DSS-induced colitis rats treated with OXY (5 mg/kg) group; OXY-5, rats treated with OXY (5 mg/kg) alone group. The values are expressed as mean ± SEM. Significant differences among groups were evaluated via ANOVA with Tukey’s post hoc HSD. *** p < 0.001 compared with the NC group; ## p < 0.01 and ### p < 0.001 compared with the model group.