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Schematic diagram of the ERK/MAKP signaling pathway in colorectal cancer. Initiation with an extracellular stimulus, EGFR ligand, which binds to and activates the EGFR receptor on the cell membrane. Downstream activation of RAS, RAF, and MEK, in that order, converges in the activation of the ERK1/2 transcription factor activator. This pathway ultimately induces cell proliferation, apoptosis, differentiation, angiogenesis, and metastases.
