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. 2021 May 3;13(9):2201. doi: 10.3390/cancers13092201
AKT protein kinase B (PKB)
APC adenomatous polyposis coli
BAX Bcl-2-associated X protein
BRAF v-raf murine sarcoma viral oncogene homolog B1
CDKN2A cyclin-dependent kinase inhibitor 2A
CMS consensus molecular subgroups
CRC colorectal cancer
CRAF proto-oncogene serine/threonine-protein kinase
DFS Disease free survival
DNA desoxyribonucleic acid
EGFR epidermal growth factor
ERK extracellular signal-regulated kinase
FAP familial adenomatous polyposis
GDP guanine 5′-triphosphate
GRB2 growth factor receptor-bound protein 2
GTP guanine 5′-diphosphate
GTPase guanine 5′-triphosphatase
ICB immune check points blocker
KRAS Kristen rat sarcoma
MAPK mitogen-associated protein kinase
MSI microsatellite instability
MSI-H high level of microsatellite instability
MSS microsatellite stable
MYC c-myc
OS overall survival
PFS progression-free survival
PD-1 programmed cell death 1
PDL-1 programmed death-ligand 1
PIK3CA phosphatidylinositol-4, 5-biphosphate 3-kinase catalytic subunit alpha
RALGDS ral guanine nucleotide dissociation stimulator
RAS rat sarcoma
RTK receptor tyrosine kinase
SHP2 tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
SMAD4 mothers against decapentaplegic homolog 4
SOS son of sevenless
STK11 serine/threonine kinase 11
TGF-β transforming growth factor beta
TP53 tumor protein 53