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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Mol Psychiatry. 2020 Feb 25;26(6):2187–2199. doi: 10.1038/s41380-020-0690-z

Figure 5-. Ethanol Drinking Alters the Excitability of PDYN Neurons in A Sex-Specific Manner.

Figure 5-

(a-e) Data collected from male mice. (a)There was no effect of ethanol drinking on resting membrane potential t(16.833)=0.076, p=0.940. (b) Ethanol drinking did not change action potential threshold t(16.947)=0.111, p=0.912. (c) There was no significant difference in the amount of current injected needed to elicit an action potential t(13.279)=0.860, p=0.405. (d) Representative traces of PDYN-neuron firing in CeA. (e) There was a significant interaction between ethanol drinking and the number of action potentials fired in the VI plot F(10,160)=2.004, p=0.036. (f-j) Data collected from female mice. (f) There was no effect of ethanol drinking on resting membrane potential t(13.681)=0.101, p=0.920. (g) Action potential threshold t(13.248)=1.120, p=0.283 or (h) rheobase t(13.386)=0.568, p=0.579. (i) Representative traces of CeA PDYN-neuron firing. (j) Ethanol drinking resulted in a nonsignificant decrease in the number of action potentials fired in the VI plot F(1,16)=2.523, p=0.132. (a-e) Water males: n=10 cells from n=6 mice; ethanol male: n=9 cells from N=6 mice; (f-j) water females: n=8 cells from n=5 mice; ethanol female n=9 from n=5 mice