Table 1.
Known ABC transporters in non-pathogenic yeasts.
| Phylogeny | Species | Gene Name | UniProt ID | Length | Substrates | References | |
|---|---|---|---|---|---|---|---|
| Exporter type II | ABCG/PDR | S. cerevisiae | PDR5 | P33302 | 1511 | Drugs, PC, PE, PS, Steroids, Herbicides | [163,164,165,166,167,168,169,170,171,172] |
| PDR10 | P51533 | 1564 | Regulate PDR12 trafficking, Herbicides, Lipids | [173,174,175] | |||
| PDR11 | P40550 | 1411 | Sterol | [99,176] | |||
| PDR12 | Q02785 | 1511 | Weak acids, Fluorescein | [177,178] | |||
| PDR15 | Q04182 | 1529 | Herbicide, Detergent | [174,175,179] | |||
| PDR18 | P53756 | 1333 | Herbicides, Ethanol, Ergosterol | [180,181,182,183] | |||
| AUS1 | Q08409 | 1394 | Sterol | [99,158,184] | |||
| SNQ2 | P32568 | 1501 | Drugs, Steroids, Mutagens, Chemicals | [169,185,186] | |||
| S. pombe | BFR1 | P41820 | 1530 | Brefeldin A, Tributyltin | [187] | ||
| Exporter type I | ABCB/MDR | S. cerevisiae | ATM1 * | P40416 | 690 | Fe/S proteins | [188,189,190] |
| MDL1 * | P33310 | 695 | Peptides | [191,192] | |||
| STE6 | P12866 | 1290 | a-factor | [193,194] | |||
| S. pombe | HMT1 * | Q02592 | 830 | Phytochelatin conjugated Cd2+ | [195,196] | ||
| MAM1 | P78966 | 1336 | M-factor | [195,196] | |||
| ABCC/MRP | S. cerevisiae | YOR1 | P53049 | 1477 | Oligomycin, Reveromycin, Beavericin, Metal ions | [197] | |
| YCF1 * | P39109 | 1515 | GS-conjug. Cd2+, Metals | [170,198,199,200] | |||
| YBT1 * | P32386 | 1661 | Metal ions, Bile acid, PC | [201,202] | |||
| VMR1 * | P38735 | 1592 | Drugs, Metal ions | [203] | |||
| BPT1 * | P14772 | 1559 | Metal ions, Bile acid, GS-conjugates | [204] | |||
| S. pombe | PMD1 | P36619 | 1362 | Drugs | [205] |
* All transporters located in the plasma membrane, except for Atm1, Mlt1 and Ybt1, Vmr1, Ycf1 and Hmt1, residing in the mitochondrial and vacuolar membrane. GS: glutathione, PC: phosphatidylcholine, PE: phosphatidylethanolamine, PS: phosphatidylserine.