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PGC1α deletion affects bone. (A) Representative images of micro-CT-generated sections of the tibia midshaft of PGC1α+/+ and PGC1α−/− mice show a reduction in cortical thickness (Ct. Th) in the absence of PGC1α. Adapted from [12]. (B) Schematic representation of the effect of PGC1α deletion in osteoblasts consisting of the reduction of Ocn and Col1a1 levels.
