Figure 3.

Dependence of intracellular Ca²⁺ dyshomeostasis on the binding affinities of Aβ42 oligomers to cellular membranes with different GM1 content. Changes in the intracellular Ca²⁺ levels plotted against the fraction of oligomer binding to the plasma membrane in GM1-modulated SH-SY5Y neuroblastoma cells treated for 1 h with 10 μM A+ (violet) or A− (green) oligomers of Aβ42 formed according to Ladiwala’s protocol [151]. Reprinted from Figure 3B, Evangelisti et al., 2016, licensed under Creative Commons Attribution 4.0 International Public License (CC BY 4.0; https://creativecommons.org/licenses/by/4.0/ (accessed on 5 May 2021)) [77].