Figure 3.

ATRX alterations and integrated representation in poorly differentiated pleomorphic sarcomas (cohort 2). (A) ATRX alterations are color-coded by their type, and shapes represent histotypes. Numbers in bubbles indicate a tumor sample (legend at the top). Translated consequences on ATRX protein is annotated above a protein schematic representation for mutations, or be-low for fusion transcripts. (B) Integrated representation shows ATRX alterations, mRNA expression (by quartile), ALT mechanism phenotype, histotypes, tumor site, FNCLCC grade, presence or not of metastasis and sex of each patient. Tumors are ordered by ATRX status, ALT phenotype, mRNA expression and histotypes. (C) Association between ATRX status and its mRNA expression (log2(FPKM+1)). (D) Relation between ATRX status and ALT phenotype.