Table 2.

Description of the products of the genes in Table 1. Function retrieved from https://string-db.org/ (accessed on 10 April 2021).

Gene	Ensembl Identifier	Protein	Function (Information Obtained from STRING Data Base)
SNCA	ENSP00000338345	α-synuclein	Involved in regulating dopamine release and transport. Induces the fibrillization of tau protein. Reduces neuronal responsiveness to different apoptotic stimuli, thus promoting a decreased caspase-3 activation.
LRRK2	ENSP00000298910	Leucine-rich repeat serine/threonine-protein kinase 2	Regulates autophagy in a positive way by means of the calcium- dependent activation of the CaMKK/AMPK pathway, also involving the activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increases in lysosomal pH, and release of Ca++ from lysosomes.
GBA	ENSP00000314508	Glucosylceramidase beta	Involved in the hydrolization of glucocerebroside. Localized in lysosomes.
UCHL1	ENSP00000284440	Ubiquitin carboxyl-terminal hydrolase isozyme L1	Deubiquitinating enzyme, generates ubiquitin monomers. Might prevent the degradation of monoubiquitin in lysosomes. Its expression is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors.
VPS35	ENSP00000299138	Vacuolar protein sorting-associated protein 35	Involved in autophagy. Is part of the retromer cargo-selective complex (CSC), which is responsible for transporting select cargo proteins between vesicular structures (e.g., endosomes, lysosomes, vacuoles) and the Golgi apparatus.
PRKN	ENSP00000355865	E3 ubiquitin-protein ligase parkin	Ubiquitin ligase; covalently binds ubiquitin residues onto proteins. Involved in the removal of abnormally folded or damaged proteins thanks to ‘Lys-63’-linked polyubiquitination of misfolded proteins.
PINK1	ENSP00000364204	Serine/threonine-protein kinase PINK1	Localized in mitochondria. Protects cells against stress-induced mitochondrial dysfunction by phosphorylating mitochondrial proteins. By means of activation and translocation of PRKN participates in the clearance of damaged mitochondria via selective autophagy (mitophagy).
ATP13A2	ENSP00000327214	Cation-transporting ATPase 13A2	ATPase involved in the transport of divalent transition metal cations and the maintenance of neuronal integrity. It is necessary for a correct lysosomal and mitochondrial maintenance.
PLA2G6	ENSP00000333142	85/88 kDa calcium-independent phospholipase A2	Involved in the release of fatty acids from phospholipids. Implicated in normal phospholipid remodeling. It has also been involved in NO- or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production.
DNAJC6	ENSP00000360108	Putative tyrosine-protein phosphatase auxilin	Promotes uncoating of clathrin-coated vesicles by recruiting HSPA8/HSC70 to clathrin-coated vesicles. Involved in clathrin-mediated endocytosis in neurons.
SYNJ1	ENSP00000409667	Synaptojanin-1	Phosphoinositide phosphatase, regulates levels of membrane phosphatidylinositol-4,5-bisphosphate (PIP2). Involved in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 by means of hydrolyzing PIP2 bound to actin regulatory proteins.
DJ-1/ PARK7	ENSP00000418770	Protein/nucleic acid deglycase DJ-1	Under an oxidative condition, via its chaperone activity, inhibits the aggregation of α-synuclein, thus functioning as a redox-sensitive chaperone and as a sensor for oxidative stress. Deglycates proteins and nucleotides, and the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals.
FBXO7	ENSP00000266087	F-box only protein 7	Part of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex involved in protein ubiquitination. Role in the clearance of damaged mitochondria (mitophagy).