Table 3.
Summary of mTOR inhibitor side effects.
| Side Effect | Number of Particular Adverse Events | |
|---|---|---|
| Everolimus | Sirolimus | |
| dyslipidemia (mostly hypertriglicerydemia) | 6 | 3 |
| transient lymphopenia | 3 | 0 |
| infections | 3 | 1 (sepsis) |
| mouth ulcers/mucositis | 2 | 1 |
| acne | 2 | 0 |
| changes in phosphate levels | 2 | 0 |
| increased cholinesterase | 2 | 0 |
| transient neutropenia | 2 | 1 |
| diarrhea/constipation | 1 | 1 |
| transient hypokalemia | 1 | 0 |
| transient anemia | 1 | 0 |
| pulmonary hemorrhage | 1 | 0 |
| elevated liver enzymes | 1 | 0 |
| decreased CD4/CD8 ratio | 1 | 0 |
| hyponatremia | 1 (association with everolimus is doubtful because the patient also received diuretics) | 0 |
| fever without evidence of infection | 0 | 1 |
| none reported (no. of patients) | 7 | 4 |
| no data (no. of studies) | 7 | 2 |
Patients in whom side effects were monitored (n = 33). There was a possibility of more than 1 adverse event per patient.