Table 3.
Potent NO inhibitors with higher potential to inhibit NO production in LPS-activated microglia with lower IC50 than the positive control named as L-NMMA.
| No. | Potential NO Inhibitor | IC50 (μM) |
|---|---|---|
| 1. | Sambucasinol B | 0.9 |
| 2. | Erythro-(7S,8R)-Guaiacylglycerol-β-coniferyl aldehyde ether | 0.925 |
| 3. | Threo-(7R,8R)-Guaiacylglycerol-β-coniferyl aldehyde ether | 1.05 |
| 4. | sambucuside E | 1.2 |
| 5. | sambucuside C | 1.3 |
| 6. | Betulinic acid | 2.38 |
| 7. | Equol | 3.45 |
| 8. | (+)-faurinone | 3.67 |
| 9. | Maslinic acid | 4.46 |
| 10. | 2α-O-benzoyl-3β,19α-dihydroxy-urs-12-en-28-oic acid | 4.92 |
| 11. | Obtusifolisides B | 5.45 |
| 12. | 23-hydroxybetulinic acid | 6.7 |
| 13. | Sulforaphane | 5.85 |
| 14. | Sambucasinol A | 6.82 |
| 15. | 1-cinnamoyltrichilinin | 7.73 |
| 16. | Morolic acid 3-O-caffeate | 8.62 |
| 17. | kaempferol | 8.86 |
| 18. | Erythro-syringylglycerol-8-O-4′-coniferyl alcohol ether | 9.14 |
| 19. | 2α-O-benzoyl-19α-hydroxy-3-oxo-urs-12-en-28-oic acid | 9.68 |
| 20. | Methoxy-Balanophonin | 10 |
| 21. | Balanophonin | 10.25 |
| 22. | Ilimaquinone | 10.4 |
| 23. | Genistein | 10.63 |
| 24. | Oleuropein | 11.17 |
| 25. | Costic acid | 12.13 |
| 26. | (+)-lyoniresinol | 12.31 |
| 27. | Holophyllane A | 12.74 |
| 28. | Ilexgenin B | 12.72 |
| 29. | 3-O-cis-caffeoylbetulinic | 13.4 |
| 30. | Daidzein | 14.09 |
| 31. | Alphitolic acid | 14.5 |
| 32. | Dihydrodehydroconiferyl alcohol | 14.6 |
| 33. | Neonuezhenide | 14.69 |
| 34. | Ilicic acid | 14.92 |
| 35. | Trichilinin B | 15.28 |
| 36. | Eudeglaucone | 15.9 |
| 37. | (2″R)-2″- methoxyoleuropein | 15.45 |
| 38. | Fraxetin | 18.72 |
| 39. | 1-desacetylnimbolinin B | 18.75 |
| 40. | L-NMMA | 20.53 |