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. 2021 Apr 28;13(9):2130. doi: 10.3390/cancers13092130

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Biomarker panel building. Median AUC values for multi-miRNA biomarker panels identified through (a) a focused search and (c) an unbiased search in the Discovery Cohort. AUC values for optimal multi-miRNA biomarker panels from the (b) focused search and (d) unbiased search validated in the Validation cohort. The focused search refers to a search among the 8 top-ranked differentially regulated miRNAs only while the unbiased search expanded the search to all 324 miRNAs analysed in this study.