Table 3.

List of altered metabolite levels identified in breast tissue of breast cancer patients to study clinicopathological factors.

Metabolite	ER+ vs. ER−				PR+ vs. PR−		HER2+ vs. HER2−		High G vs. Low G			TN vs. NonTN			N+ vs. N0		T > 2 cm vs. T < 2 cm	High Ki67 vs. Low Ki67
	[77]	[78]	[79]	[82]	[77]	[78]	[78]	[79]	[78]	[53]	[83]	[78]	[79]	[80]	[82]	[83]	[83]	[78]	[84]
Choline	↓	↓	↓		↓	↓						↑	↑			↓	↑
Choline/creatine												↑
Total choline/creatine												↑
Phosphatidylcholine/creatine									↑									↑
Total choline																		↑
Phosphatidylcholine	↑			↓	↓			↓					↑		↑	↑		↑
Glycine	↓		↓	↓	↓			↑					↑		↑	↑	↑
Scyllo-inositol				↓			↑
Myo-inositol							↑									↑
Glycerophosphocholine	↓			↑	↓						↑		↑			↓
Creatine	↑				↓	↓		↑					↓			↓
Glutamine			↑					↑					↓
Glutamate			↓										↑
Taurine	↑			↑		↓	↑								↓	↓
Alanine	↓				↓			↓
Ascorbate	↑				↓
Lactate	↓		↓	↓	↓											↓
Succinate								↑
ATP														↓
Lactate/Choline										↑
Betaine																↓
Glucose																↑			↓

↑/↓ higher/lower level in the first group of each comparison.