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Pericentromeric chromatin (PCH) establishment and maintenance is mediated by the ATRX-DAXX complex. DAXX binds the H3.3 and locates it to PML-NBs where the complex is assembled. The complex recognizes H3K9Me3 and promotes H3.3 deposition at PCH. Several other proteins and non-coding RNAs are involved in the process activating a “self-sustaining loop” mechanism.
