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(A) ATRX role in the maintenance of telomeric and subtelomeric chromatin. ATRX localization at telomeres is independent from SUV39H1/2 and probably is determined by SETDB1 H3K9Me3 deposition and by the action of TERRA. (B) In the absence of ATRX, TERRA expression strongly increases and DNA:RNA hybrids (R-loops) occur at telomeres hindering telomere replication and favoring the onset of recombination mediated processes at telomeres that characterize ALT cells.
