Table 1.

ATRX interactors, relative binding domains, and function.

PROTEIN	INTERACTION DOMAIN	FUNCTION	REF.
DAXX	DAXX binding domain	H3.3 deposition	[37]
EZH2	EZH2 binding domain	DNA methylation	[38]
HP1α	HP1α binding domain	DNA methylation and PCH formation	[39]
MeCP2	Mecp2 interacting region	DNA methylation and PCH formation	[40]
FANCD2	Unknown	HR	[41]
MRE11	Unknown	DNA DBS Repair, Replicative stress	[42]
NBN	Unknown	DNA DBS Repair, Replicative stress	[43]
RAD50	Unknown	DNA DBS Repair, Replicative stress	[43]
CtIP	Unknown	Replicative stress	[41]
RFC1	Unknown	HR	[44]
PCNA	Unknown	HR	[44]
MacroH2A1.1	322–841 aa	Telomere cohesion	[45,46]
MacroH2A1.2	322–841 aa *	X chromosome inactivation	[45,47]
MacroH2A2	322–841 aa *	X chromosome inactivation	[45]
XIST	RBR domain	X-chromosome inactivation	[48]
TERRA	Probably RBR domain	Telomeric maintenance	[49]
CHRO1	Probably RBR domain	Heterochromatin organization	[50]
H3K9me3	ADD domain	Heterochromatin organization	[51]
H3K4me0	ADD domain	Heterochromatin organization	[52]
SMC1	Unknown	Regulation of mitotic chromosome cohesion	[53]
SMC3	Unknown	Regulation of mitotic chromosome cohesion	[53]
ZNF274	Unknown	Heterochromatin maintenance	[54]
TRIM28	Unknown	Heterochromatin maintenance	[54]
SETDB1	Unknown	Heterochromatin maintenance	[54]

* This interaction domain is referred to MacroH2A1.1 as shown in [46] and it is conceivable to be the same for MacroH2A1.2 and MacroH2A2.