| ASIC1 |
increases in sensitivity of mechanical forces in esophageal, colonic structures and gastric emptying [92,112]. has an important visceral mechanosensation process in urothelium and bladder compliance sensation [92,112]. is expressed in cutaneous Pacinian corpuscles and may serve as rapidly adapting low-threshold mechanoreceptors [114]. has an effect on primary hyperalgesia during inflammation, which is a local response at the area of injury [115]. contributes to peripheral vasoconstriction and vascular remodeling [117]. decreases mechanosensation in PNS with peripheral tissues including arteries, bone marrow, intestine, tongue and bladder [118,119,120]. ASIC1b is involved in pain sensation [24,25].
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| ASIC2 |
is linked to nociception and mechanosensation in the DRG [122,124]. is involved in mechanosensation in autonomic nervous system via the nodose ganglia [35]. is modulated by cardiac afferents to control blood pressure [124]. ASIC2a proteins have been found in Meissner, Merkel, penicillate, reticular, lanceolate, and hair follicle palisades in rat skin [110].
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| ASIC3 |
contributes to secondary hyperalgesia [115]. is associated with visceral colonic pain [48]. vasodilates small skeletal muscle arteries during muscle stress [135]. is heavily associated with nociception and proprioception, these functions are specifically channeled through Meissner corpuscles, and Merkel cells [110]. is heavily implicated in bladder physiology by providing sensory signaling during the filling of the bladder [49]. is involved in pain sensation in the bladder associated with inflammation [112]. contributes to neuronal mechanosensation that regulates changes in pH and motion found in lamprey models [139].
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