Table 1.
The effect of VA on relative organ weight and activities of serum AST and ALT in DEN- and DMH-initiated rats. Values expressed as mean ± SD.
| Treatment | Week of Administration |
Final Body Weight (g) |
Relative Organ Weight (%) | AST (U/L) |
ALT (U/L) |
|||
|---|---|---|---|---|---|---|---|---|
| Carcinogen/NSS | VA (mg kg−1 BW) |
Liver | Spleen | Kidney | ||||
| DEN + DMH | - | - | 398.8 ± 22.8 * | 3.35 ± 0.14 | 0.25 ± 0.03 | 0.57 ± 0.03 | 109.5 ± 25.7 * | 64.8 ± 19.1 * |
| DEN + DMH | 0.75 | 10 | 383.8 ± 19.8 | 3.26 ± 0.29 | 0.24 ± 0.02 | 0.55 ± 0.03 | 116.4 ± 29.0 | 61.6 ± 8.9 |
| DEN + DMH | 75 | 10 | 399.4 ± 35.8 | 3.19 ± 0.15 | 0.21 ± 0.02 | 0.56 ± 0.02 | 110.4 ± 29.4 | 57.6 ± 8.4 |
| DEN + DMH | 0.75 | 7 | 382.5 ± 13.4 | 3.38 ± 0.18 | 0.24 ± 0.02 | 0.57 ± 0.04 | 92.9 ± 12.1 | 54.3 ± 7.43 |
| DEN + DMH | 75 | 7 | 395.0 ± 21.9 | 3.35 ± 0.17 | 0.25 ± 0.04 | 0.55 ± 0.02 | 109.4 ± 21.8 | 62.7 ± 17.8 |
| NSS | - | - | 445.0 ± 37.4 | 3.40 ± 0.11 | 0.20 ± 0.02 | 0.55 ± 0.02 | 75.5 ± 15.6 | 39.2 ± 8.3 |
| NSS | 75 | 10 | 428.0 ± 31.7 | 3.40 ± 0.31 | 0.19 ± 0.02 | 0.56 ± 0.03 | 84.6 ± 20.9 | 43.0 ± 8.4 |
* Significantly different from negative control group, p < 0.05. ALT: alanine aminotransferase, AST: aspartate aminotransferase, DEN: diethylnitrosamine, DMH: 1,2-dimethylhydrazine, NSS: normal saline solution, VA: vanillic acid.