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. 2021 May 4;22(9):4867. doi: 10.3390/ijms22094867

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The disrupting peptide also affects the surface dynamic properties of extrasynaptic GABA_A receptors. (A) Cumulative probability diffusion coefficient of extrasynaptic GABA_A receptors in control condition or in the presence of the disrupting peptide (10 µM). The inset shows the immobile fraction (defined as D < 0.005 µm²/s) of extrasynaptic GABA_A receptors in control condition and in the presence of the disrupting peptide. (B) Bar graphs illustrating the instantaneous diffusion coefficient (D, represented as median ± interquartile range 25–75%) of extrasynaptic GABA_A receptors in control condition or in the presence of the disrupting peptide. (C) Comparison of extrasynaptic GABA_A receptors mean square displacements (MSD, represented as mean ± SEM) in control condition or in the presence of the disrupting peptide. (D) Bar graphs illustrating the explored surface area (EA, represented as median ± interquartile range 25–75%) of extrasynaptic GABA_A receptors in control condition or in the presence of the disrupting peptide. *** p < 0.001. Nonparametric Mann–Whitney test.

The disrupting peptide also affects the surface dynamic properties of extrasynaptic GABA_A receptors. (A) Cumulative probability diffusion coefficient of extrasynaptic GABA_A receptors in control condition or in the presence of the disrupting peptide (10 µM). The inset shows the immobile fraction (defined as D < 0.005 µm²/s) of extrasynaptic GABA_A receptors in control condition and in the presence of the disrupting peptide. (B) Bar graphs illustrating the instantaneous diffusion coefficient (D, represented as median ± interquartile range 25–75%) of extrasynaptic GABA_A receptors in control condition or in the presence of the disrupting peptide. (C) Comparison of extrasynaptic GABA_A receptors mean square displacements (MSD, represented as mean ± SEM) in control condition or in the presence of the disrupting peptide. (D) Bar graphs illustrating the explored surface area (EA, represented as median ± interquartile range 25–75%) of extrasynaptic GABA_A receptors in control condition or in the presence of the disrupting peptide. *** p < 0.001. Nonparametric Mann–Whitney test.