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. 2021 Apr 28;22(9):4628. doi: 10.3390/ijms22094628

Figure 2.

Figure 2

Major markers of the RSV signaling cascade proposed to be beneficial toward brain health. (Blue) SIRT1 inhibition of p53 leads to a reduction in apoptosis, increases in cellular BDNF content; (Orange) SIRT1/AMPK upregulation of PCG1-α expression and activity lead to improvements in biogenesis, preventing ROS accumulation, subsequently leading to reductions in inflammatory markers; (Green) AMPK increases in autophagy-driven Aβ-peptide clearance through mTORC1 inhibition, potential impacts on synaptic plasticity and cognition. Created by Biorender.com accessed on 30 March 2021.