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. 2021 May 5;22(9):4891. doi: 10.3390/ijms22094891

Figure 1.

Figure 1

Structure of human and C. elegans dystrophin proteins. The structures of human dystrophin and C. elegans DYS-1. The size of human and C. elegans dystrophin is almost equivalent. They also share similarities in key motifs: CC, coiled coil domain; CH, calponin homology domain (“actin-binding” domain); WW, domain with two conserved W residue; ZZ, zinc finger domain. The arrows indicate the amino acid positions of the mutation sites for the commonly used mutants: cx18 and eg33 alleles, which are both nonsense mutations. Adapted from Oh and Kim (2013) [13] and Gieseler et al. (2017) [15]. Created with biorender.com.