Figure 4.

The effect of the loss of dystrophin on various processes in the mutants. Schematic of part of a muscle cell including a dense body anchored to the sarcolemma and actin/myosin filaments. The muscle arm is in close contact with a motor neuron and shows elements of the NMJ (acetylcholine (ACe), acetylcholinesterase (AchE), acetylcholine receptor (AchR)). DYS-1 has many key roles in muscle function as does the DGC that can be seen in the middle. Proteins in yellow represent those that are important for maintaining sarcolemma integrity, those in pink are muscle related, those in red are calcium related and those in blue are acetylcholine signalling related. Processes associated with loss of dystrophin can also be seen. Adapted from Gieseler et al. (2017) [15]. Created with biorender.com.