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. 2021 Apr 30;13(9):2171. doi: 10.3390/cancers13092171

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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B cell differentiation in Pparγ1^+/+ vs. Pparγ1^−/− multigenic mice. (A). Schematic representation of lineage differentiation from pro B cells to mature B cells. (B). Lineage indices of Pparγ1^+/+ vs. Pparγ1^−/− multigenic mice (Pparγ1^wt/wt, vs. Pparγ1^fl/fl, both in ROSA26^CreERT2, Rosa26^mTmG and MMTV-ErbB2 background and treated with tamoxifen) with relative distribution of B cell lineage components in the bone marrow (BM). Relative proportion of Pro-B, Pre-B, Immature B cells, and Mature B cells (B220^highIgM⁺) are shown. (C). The proportion of Mature B cells are shown for the blood and spleen. Data are represented as mean ± SEM. n = 10 total.