Figure 6.

PPARγ1 binding in chromatin to growth factor and cytokine/chemokine signaling module genes, in ErbB2 mammary tumors. (A). ChIP-Seq analysis was performed on samples derived from MCF10A-NeuT transduced with PPARγ Wt and peak calling defined by MACS2 software is shown in the Venn diagram. (B). Distribution of PPARγ Wt peaks relative to the TSS. The region upstream from the TSS was divided as indicated. (C). Integrated genome browser visualization of tag density profiles for ChIP-Seq PPARγ Wt of selected genes in the PPARγ1 target gene (PDK4), (D–G). the growth module EphA2, Amphiregulin, ADAM12, ADAMTS2 and (H,I), the interferon/cytokine module of IL1B, IL34. (J). Schematic representation of model in which PPARγ1 determines binding to cytokine/chemokine and growth factor genes.