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(A) The neurotrophin family has four members: NGF, BDNF, NT-3, and NT-4. BDNF, NT-3, and NT-4 can activate TRKB. (B) Overexpression of wild-type TRKB/BDNF in murine primary hematopoietic stem/progenitor cells induced SM. Cytospins showing strong infiltration of mature MCs in the spleen [37].
