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The ubiquitin system. This multicomponent system is made up of E1, E2 and E3 enzymes which facilitate the addition of ubiquitin moieties onto different substrate proteins. Ubiquitin modification are highly specific and are unique for each of the cellular processes they regulate. The deubiquitinating (DUB) family of enzymes allow for the removal of ubiquitin modification and replenishes the free ubiquitin pool within the cell.
