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. 2021 May 6;13(9):2218. doi: 10.3390/cancers13092218

Figure 2.

Figure 2

ADPN effects in BC cells. ADPN isoforms and their receptors regulate several signaling pathways to control BC cell behavior. However, it has been reported that ADPN can have anti- or pro-oncogenic effects depending on the ER status. PPARα—peroxisome proliferator activated receptor alpha; TSC2—tuberous sclerosis 2; TFs—Transcription factors; EGR1—early growth response 1; CCND1—cyclin D1; BCL2 apoptosis regulator; VEGF—vascular endothelial growth factor; HIF1A—hypoxia inducible factor 1 subunit alpha; CDKN1A—cyclin dependent kinase inhibitor 1A; PPP2CA—protein phosphatase 2 catalytic subunit alpha; TP53—tumor protein p53; BAX—BCL2 associated X, apoptosis regulator; CDKN1B—cyclin dependent kinase inhibitor 1B.