Skip to main content
. 2021 May 6;13(9):2218. doi: 10.3390/cancers13092218

Figure 3.

Figure 3

LEP effects in BC cells. LEP and Ob-Rs activate classical signaling pathways to regulate the expression of genes related to increased BC development independently of the ER status. TKRs—tyrosine kinase receptors; EGFR—epidermal growth factor receptor; JAK2—janus kinase 2; STAT3—signal transducer and activator of transcription 3; GRB2—growth factor receptor bound protein 2; SHP2—protein tyrosine phosphatase non-receptor type 11; IRS2—insulin receptor substrate 2; TWISTS1—twist family bHLH transcription factor 1; TERT—telomerase reverse transcriptase; SNAI1—snail family transcriptional repressor 1; TNF—tumor necrosis factor; PKM—pyruvate kinase M1/2; ILs—Interleukins; CDH1—E-cadherin; VIM—vimentin.