Table 1.

Canonical pathways heat map displaying the most significant results (ordered by decreasing z-scores in females, then in males) across datasets in 45% HFD vs. control (left panel) and in 60% HFD vs. control (right panel). The orange and blue-colored rectangles indicate predicted pathway activation or predicted inhibition, respectively, via the z-score statistic. Pathways in common between the diet regimens are shown in italics.

Canonical Pathways 45% HFD/CTR	Females	Males	Canonical Pathways 60% HFD/CTR	Females	Males
Oxidative phosphorylation	3	0	Oxidative phosphorylation	3.162	−2.5
TCA cycle II (eukaryotic)	2.236	2.646	TCA cycle II (eukaryotic)	2.449	0.378
Actin cytoskeleton-signaling	N/A	3.207	Glycolysis I	N/A	2.121
Estrogen-receptor-signaling	N/A	2.449
Regulation of actin-based motility by Rho	N/A	2.236
Gluconeogenesis I	N/A	2.236
ILK-signaling	N/A	2.138
Protein kinase A-signaling	N/A	−2.236
RhoGDI-signaling	N/A	−2.449

Italics identifies items in common between diet regimens.