Table 2.

Diseases and biofunctions heat map displaying the most significant results (ordered by decreasing z-scores in females, then in males) across datasets in 45% HFD vs. control (left panel) and in 60% HFD vs. control (right panel). The orange and blue-colored rectangles indicate predicted pathway activation or inhibition, respectively, via the z-score statistic. Functions in common between the diet regimens are shown in italics.

Diseases and Bio Functions 45% HFD/CTR	Females	Males	Diseases and Bio Functions 60% HFD/CTR	Females	Males
Cell death of muscle cells	−2	0.302	Concentration of lipid	N/A	2.779
Necrosis of muscle	−2.236	N/A	Concentration of fatty acid	N/A	1.99
Necrosis	−2.927	0.154	Transmembrane potential of mitochondria	N/A	−1.964
Damage of muscle	N/A	1.982	Consumption of oxygen	N/A	−1.982
Quantity of glycogen	N/A	1.977
Quantity of carbohydrate	N/A	1.821
Concentration of fatty acid	N/A	1.65
Cellular homeostasis	N/A	−1.644
Transmembrane potential	N/A	−2.2
Transmembrane potential of mitochondria	N/A	−2.2

Italics identifies items in common between diet regimens.