Table 3.

Upstream regulators heat map displaying the most significant results (ordered by decreasing z-scores in females, then in males) across datasets in 45% HFD vs. control (left panel) and in 60% HFD vs. control (right panel). The orange and blue-colored rectangles indicate predicted regulator activation or inhibition, respectively, via the z-score statistic. Regulators in common between the diet regimens are shown in italics.

Upstream Regulators 45% HFD/CTR	Females	Males	Upstream Regulators 60% HFD/CTR	Females	Males
Insr	3.561	2.02	Insr	3.38	0.191
Ppargc1a	3.124	0.904	Ppargc1a	3.279	−0.299
Rb1	2.449	0.335	Rb1	2.333	−0.709
Igf1r	2.236	0.632	Igf1r	2.236	−0.905
Esrra	2.219	0.154	Pten	2.182	0.688
Ppargc1b	2	1.026	Stk11	2.121	0.471
Myc	0.831	2.213	Ppargc1b	2	−0.396
Nr4a1	−1	−3.174	Map4k4	−2.236	0.535
Tp53	−2.111	−1.035	Kdm5a	−2.333	0.816
Kdm5a	−2.449	−0.626	Tp53	−2.887	−0.671
Rictor	−3	−0.258	Rictor	−3.162	2
Clpp	−3.051	−2.449	Clpp	−3.207	0.209
Cpt1b	−3.138	−0.249	Cpt1b	−3.293	2.467
Pparg	N/A	−2.18	Hif1a	N/A	2.211
			Rptor	N/A	2.425

Italics identifies items in common between diet regimens.