Figure 2.

Physiological parameters. (A): In the normothermic vehicle-treated (VEH) and SZR72-treated (SZR72) groups, rectal temperature was maintained at 38.5 °C throughout the experiments. The hypothermia-treated (HT) group was also normothermic at baseline (BL) and during the asphyxia (ASPH); however, the rectal temperature reached therapeutic levels at 33.5 °C by 1 h after asphyxia and was maintained at that level for the rest of the observation period. (B): mean arterial blood pressure (MABP) was within the normal range for all groups, although it was significantly lower in the HT group at the end of the asphyxia. There was no significant difference between the VEH and the SZR72 groups over the whole observation period, but it tended to be lower in the HT group that reached statistical significance first at 14 h. (C): heart rate was elevated by asphyxia from baseline levels, and it remained elevated in the normothermic groups throughout the observation period. There was a tendency for a somewhat smaller heart rate in the SZR72 group; however, there was no significant difference between the groups except at 13 h after asphyxia. As expected, hypothermia significantly reduced the heart rate that was significantly different from the corresponding values of the VEH group at most time points. * p < 0.05, significantly different from the corresponding value of the VEH group for all time points in the brackets and also for individual time points. Significant differences from the respective baselines within the groups are not indicated for clarity.