Figure 4.

Serum levels of SZR72, kynurenine, and kynurenic acid (KYNA). (A): SZR72 levels were highest at 1 h after asphyxia reflecting the effect of bolus drug administration, then they were gradually decreased and stabilized in 50–100 µmol/L range. (B): Kynurenine levels were similar among the different groups at baseline (BL), and they were largely unaffected by asphyxia, except there was a statistically significant elevation in the VEH group at 24 h. (C): KYNA levels were similar among the different groups at BL, and they were unchanged in the VEH and HT groups after asphyxia, but they were increased 10-fold in the SZR72 group (note the log scale of C). *, †, ‡ p < 0.05, significantly different from the corresponding value of the VEH group, from the respective baseline value of the group, or from the respective 1 h value of the group, respectively.