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. 2021 Apr 28;22(9):4613. doi: 10.3390/ijms22094613

Table 1.

Ion Channels involved in Wnt signaling.

Channels Ions Gated Effect Cell Types and Diseases Ref.
Kv7.1, K+ Tumor suppression by inactivation of the B catenin in the cytoplasm Colon and Hepatic carcinoma [51,52]
Kv11.1 K+ Channel activity inactivates β-catenin, preventing nuclear importation Breast cancer [41]
CFTR Cl- Tumor suppressor, CFTR activity contributes to the correct functionality of the complex FZD-LRP-Wnt. Cystic fibrosis [53]
TRPV4 Ca2+ TRPV4-mediated Ca2+ entry from the extracellular space promotes β-catenin activation by AKT modulation Gastric cancer [54]
TrpC5 Ca2+ TrpC5 overexpression favors the nuclear accumulation of β-catenin by Ca2+ Colorectal cancer [55]