Table 1.
Channels | Ions Gated | Effect | Cell Types and Diseases | Ref. |
---|---|---|---|---|
Kv7.1, | K+ | Tumor suppression by inactivation of the B catenin in the cytoplasm | Colon and Hepatic carcinoma | [51,52] |
Kv11.1 | K+ | Channel activity inactivates β-catenin, preventing nuclear importation | Breast cancer | [41] |
CFTR | Cl- | Tumor suppressor, CFTR activity contributes to the correct functionality of the complex FZD-LRP-Wnt. | Cystic fibrosis | [53] |
TRPV4 | Ca2+ | TRPV4-mediated Ca2+ entry from the extracellular space promotes β-catenin activation by AKT modulation | Gastric cancer | [54] |
TrpC5 | Ca2+ | TrpC5 overexpression favors the nuclear accumulation of β-catenin by Ca2+ | Colorectal cancer | [55] |